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Amyloids

We are interested in deciphering the fibrillation processes of amyloid peptides and their relationship with disease. In particular, we study the effect of membranes upon fibrillation processes of varied pathogenic and functional amyloidogenic proteins. We have also explored interactions of nanoparticles with amyloid proteins, and the contributions of protein/protein interactions to amyloid fibril formation and amyloid toxicity.

RECENT PUBLICATIONS

  • Modulation of tau amyloid assemblies associated with Alzheimer’s disease by Naphthoquinone-Dopamine hybrid, Ashim Paul, Guru KrishnaKumar Viswanathan, Adi Huber, Elad Arad, Hamutal Engel, Raz Jelinek, Ehud Gazit, Daniel Segal FEBS Journal, 2021, in press.

  • 15.Vesicle-based assays to study membrane interactions of amyloid peptides, Ravit Malishev, Raz Jelinek, Proteins in Misfolding Diseases, Springer Protocols – Methods in Molecular Biology, 2018, 1873, 39-52.

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